Using 4-nitrophenol (4-NP) as template, novel magnetic imprinted particles were prepared via surface molecular imprinting. TEM graph reveals the MIPs owned a core-shell structure. VSM measurement manifests the MIPs were superparamagnetic, this feature provided the MIPs with easy fixity and separation capability when they were used in environmental protection. Using these MIPs and a commercial photocatalyst, we constructed a double-domain film with molecular recognition sites (MRS) and photocatalytic sites (PCS) for the first time. Since MRS was located in the vicinity of titanium dioxide domains, surface-diffusion of the contaminants from MRS to PCS was easily achieved, resulting in enhanced photodecomposition of the highly toxic targets. The synergistic effect of molecular imprinting and photocatalysis provides a promising method for selective removal of the highly toxic contaminants from wastewater. (C) 2012 Elsevier B.V. All rights reserved.