Prussian blue analogue of porous Mn-3[Co(CN)(6)](2)center dot nH(2)O nanospheres with a large surface area were prepared by simple mixing K-3[Co(CN)(6)](2) and manganous nitrate solution at room temperature. The morphology and structure of the prepared products were characterized by XRD, FE-SEM, TEM, and BET. The results indicated that the product was composed of nanospheres with the diameter of approximate to 250 nm, which was of porous structure with the pore diameter in the 2.5-4 nm range. The adsorption behavior of Cu(II) ions from aqueous solution onto porous nanospheres was investigated as a function of parameters, such as the equilibrium time, the pH, the initial concentration, and the temperature. A maximum adsorption capacity of 140.85 mg g(-1) of Cu(II) was achieved. Due to the simple synthetic method and its high adsorption capacity, the porous nanospheres had the potential to be utilized as an effective adsorbent for Cu(II) removal.