The solvent extraction of Ti(IV) from sulfate medium by the commercial extractant Cyanex 301 (HA) has been studied in order to examine this novel system. Heptan-1-ol (5% (v/v) in the organic phase) is used as a de-emulsifier. The equilibration time is 45min. The experimental results suggest that the extracted species is always TiOA(2 (o)), though the composition of the reacting aqueous Ti(IV) species may vary depending on the concentration levels of Ti(IV), pH, HA and SO42-. The equilibrium constant (K-ex) at 303K is measured to be 10(1.117) and 10(-1.243) for the reaction of monomeric, non-sulfated, mono, and non-hydrolyzed TiO2+, respectively. The effects of heptan-1-ol, temperature, loading, and diluent type have been reported. Stripping can be done effectively by a solution of 1mol/dm(3) H2SO4 containing 5%(v/v) of 100 volume H2O2. The possibilities of separation of Ti(IV) from Cu(II), Zn(II), Fe(III), Co(II), and Ni(II) have been predicted. It is proved to be an effective extractant for Ti(IV)/Fe(III) separation from sulphate medium at pH similar to 1.