Image-based computations of relative permeability for capillary-dominated quasi-static displacements require a realistic description of the distribution of the fluids in the pore space. The fluid distributions are usually computed directly on the imaged pore space or on simplified representations of the pore space extracted from the images using a wide variety of models which capture the physics of pore-scale displacements. Currently this is only possible for uniform strongly wetting conditions where fluid-fluid and rock-fluid interactions at the pore-scale can be modelled with a degree of certainty. Recent advances in imaging technologies which make it possible to visualize the actual fluid distributions in the pore space have the potential to overcome this limitation by allowing relative permeabilities to be computed directly from the imaged fluid distributions. The present study explores the feasibility of doing this by comparing laboratory measured capillary-dominated drainage relative permeabilities with relative permeabilities computed from micro-CT images of the actual fluid distributions in the same rock. The agreement between the measurements and the fluid image-based computations is encouraging. The paper highlights a number of experimental difficulties encountered in the study which should serve as a useful guide for the design of future studies.