This paper deals with the synthesis and characterization of compounds with antibacterial activity: quaternary phosphonium salts grafted on macromolecular supports by polymer-analogous reactions. The products were proved to have antibacterial activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. A great advantage was that the active species grafted on insoluble carriers could be used in repeated cycles, only needing sterilization prior to use. (C) 2002 Elsevier Science B.V. All rights reserved.