This paper proposes a novel, model-based control strategy for absorption cooling systems. First, a small-scale absorption chiller was modelled using artificial neural networks (ANNs). This model takes into account inlet and outlet temperatures as well as the flow rates of the external water circuits. The configuration 9-6-2 (9 inputs, 6 hidden and 2 output neurons) showed excel.ent agreement between the prediction and the experimental data (R(2)>0.99 and RMSE < 0.05%). This type of ANN model is used to explain the behaviour of the system when operating conditions are measured and these measurements are available. A control strategy was also developed by using the inverse artificial neural network (ANNi) method. For a particular output (cooling load) the ANNi calculates the optimal unknown parameter(s) (controlling temperatures and flow rates). An optimization method was used to fit the unknown parameters of the ANNi method. The very low percentage of error and short computing time make this methodology suitable for the on-line control of absorption cooling systems. (C) 2011 Elsevier Ltd. All rights reserved.