Preparation and Swelling Behavior of Biodegradable Poly(aspartic acid)-Based Hydrogel

Seok Kee Min; Soo Hyun Kim; Ji-Heung Kim

Journal of Industrial and Engineering Chemistry, Vol.6, No.4, 276-279, July, 2000

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Preparation and Swelling Behavior of Biodegradable Poly(aspartic acid)-Based Hydrogel

Seok Kee Min, Soo Hyun Kim¹, and Ji-Heung Kim^{1, †}

Department of Chemical Engineering, Sungkyunkwan University, Kyunggi 440-746, Korea
¹Biomaterials Research Center, Korea Institute of Science & Technology, Seoul 136-791, Korea

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High molecular weight polysuccinimide(PSI), as the precursor polymer for water-soluble poly(aspartic acid), was prepared by the thermal polycondensation of L-Aspartic acid. The molecular weight, estimated from the solution viscosity of the PSI, was within a range of 100000~140000 Dalton. A crosslinked gel powder was prepared by the thermal curing reaction of a freeze-dried mixture composed of polyaspartic acid and a proper amount of PEG-diepoxide in water. The dependences of welling behavior on the composition and curing conditions were also investigated.

Keywords:polysuccinimide/ poly(aspartic acid)/ hydrogel/ swelling/ crosslinking

[References]

Paik YH, Swift G, Simon ES, European Patent, 0,578,451 A2 (1994)
Giammona G, Pitarresi G, Tomarchio V, Spadaro G, Colloid Polym. Sci., 272, 12 (1994)
Wolk SK, Swift G, Paik YH, Yocom KM, Smith RL, Simon ES, Macromolecules, 27(26), 7613 (1994)
Freeman MB, European Patent, 0,593,187 A1 (1994)
Nakato T, Yoshitake M, Matsubara K, Tomida M, Kakuchi T, Macromolecules, 31(7), 2107 (1998)
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Nakato T, Kusuno A, Kakuchi T, J. Polym. Sci. A-Polym. Chem., 38(1), 117 (2000)
Wood LL, U.S. Patent, 5,288,783 (1994)
Matsubara K, Nakato T, Tomida M, Macromolecules, 30(8), 2305 (1997)
Tamatai H, Nagatomo A, Ajioka M, Yamaguchi A, ANTEC, 1511 (1995)
Andrade JD, Hydrogels for Medical and Related Application, ACS Symposium Series 31, American Chemical Society, Washington, D.C. (1996)
Allen DA, Modern Superabsorbent Polymer Technology F.L. Buchholz and A.T. Graham Eds., John Wiley & Sons, New York, Ch. 6 (1998)
Tomida M, Yabe M, Arakawa Y, Kunioka M, Polymer, 38(11), 2791 (1997)

[Referenced By]

[Related Articles]

[1] Paik YH, Swift G, Simon ES, European Patent, 0,578,451 A2 (1994)

[2] Giammona G, Pitarresi G, Tomarchio V, Spadaro G, Colloid Polym. Sci., 272, 12 (1994)

[3] Wolk SK, Swift G, Paik YH, Yocom KM, Smith RL, Simon ES, Macromolecules, 27(26), 7613 (1994)

[4] Freeman MB, European Patent, 0,593,187 A1 (1994)

[5] Nakato T, Yoshitake M, Matsubara K, Tomida M, Kakuchi T, Macromolecules, 31(7), 2107 (1998)

[6] Neri P, Antoni G, Benvenuti F, Colola F, Gazzei G, J. Medicinal Chem., 16, 893 (1972)

[7] Wheeler AP, Kosan LP, Mater. Res. Soc. Symp. Proc., 292, 279 (1993)

[8] Nakato T, Kuramochi M, Matsubara K, Tomida M, ACS Polym. Prepr., 31(1), 555 (1996)

[9] Nakato T, Kusuno A, Kakuchi T, J. Polym. Sci. A-Polym. Chem., 38(1), 117 (2000)

[10] Wood LL, U.S. Patent, 5,288,783 (1994)

[11] Matsubara K, Nakato T, Tomida M, Macromolecules, 30(8), 2305 (1997)

[12] Tamatai H, Nagatomo A, Ajioka M, Yamaguchi A, ANTEC, 1511 (1995)

[13] Andrade JD, Hydrogels for Medical and Related Application, ACS Symposium Series 31, American Chemical Society, Washington, D.C. (1996)

[14] Allen DA, Modern Superabsorbent Polymer Technology F.L. Buchholz and A.T. Graham Eds., John Wiley & Sons, New York, Ch. 6 (1998)

[15] Tomida M, Yabe M, Arakawa Y, Kunioka M, Polymer, 38(11), 2791 (1997)