Desiccant cooling is an alternative technique to vapour compression systems. When thermally driven at moderate temperatures, it can be coupled to solar collectors. The use of flat-plate collectors and air collectors has demonstrated low efficiency in the coupling process and so a low potential of solar energy use in desiccant cooling. In this paper the use of heat pipe vacuum tube (HPVT) collectors in a solar desiccant cooling set up is investigated. First, a model for the collectors is proposed and experimentally validated under various operating conditions. A model of the storage tank taking into account thermal stratification is also validated. The experimentally evaluated efficiency of the HPVT collectors for one operating day varies between 0.6 and 0.7. Finally, simulation of the solar desiccant plant cooling a building is performed for different climates over a summer season. The solar fraction and the overall efficiency of the solar plant are calculated for this period and the potential of the vacuum tube collectors is evaluated for application to the desiccant cooling process. (C) 2008 Elsevier Ltd. All rights reserved.