Electric lighting is responsible for up to one third of an office building's electricity needs. Making daylight more available in office buildings can not only contribute to significant energy savings but also enhance the occupants' performance and wellbeing. Anidolic Day lighting Systems (ADS) are one type of very effective facade-integrated daylighting systems. All south-facing office rooms within the LESO solar experimental building in Lausanne (Switzerland) are equipped with a given type of ADS. A recent study has shown that these offices' occupants are highly satisfied with their lighting environment. The most energy-efficient south-facing offices have a lighting power density of less than 5 W/m(2). The lighting situation within these "best practice"-offices has been assessed using the lighting simulation software RELUX Vision. Because this lighting situation is very much appreciated by the occupants, it was used as a starting point for developing even more energy-efficient office lighting designs. Two new lighting designs, leading to lighting power densities of 3.9 W/m(2) and 3 W/m(2), respectively, have been suggested and simulated with RELUX Vision. Simulation results have shown that the expected performances of these new systems are comparable to that of the current lighting installation within the "best practice"-offices or even better. These simulation results have been confirmed during experiments on 20 human subjects in a test office room recently set up within the LESO building. This article gives engineers, architects and light planers valuable information and ideas on how to design energy-efficient and comfortable electric lighting systems in office rooms with abundant access to daylight. (C) 2009 Elsevier Ltd. All rights reserved.