This paper presents the modeling and simulation of solar-powered desiccant regenerator used for open absorption cooling cycles. The input hat, which is the total radiation incident on an inclined surface, is evaluated via a solar radiation model in terms of the location, day of the year, and time of the day. Calcium Chloride (CaCl(2)) is applied as the working desiccant in this investigation. The solar radiation model is integrated with the desiccant regenerator model to produce a more realistic simulation. A finite difference method is used to simulate the combined heat and mass transfer processes that occur in the liquid desiccant regenerator. The system of equations is solved using the Matlab-Simulink platform. The effect of the important parameters, namely the regenerator length, desiccant solution flow rate and concentration, and air flow rate, on the performance of the system is investigated. It has been found that the vapor pressure difference has a maximum value for a given regenerator length. It is also shown that for specified operating conditions, a maximum value of the coefficient of performance occurs at a given range of air and solution flow rates. Therefore, it is essential to select the design parameters for each ambient condition to maximize the coefficient of performance of the system. (C) 2011 Elsevier Ltd. All rights reserved.