Improvement single-wall carbon nanotubes (SWCNTs) based on functionalizing with monomers 2-hydroxyethylmethacryate (HEMA) and N-vinylpyrrolidone (NVP) for pharmaceutical applications as cancer therapy

Fatemeh Abbaszadeh; Omid Moradi; Mehdi Norouzi; Omid Sabzevari

Journal of Industrial and Engineering Chemistry, Vol.20, No.5, 2895-2900, September, 2014

DOI10.1016/j.jiec.2013.11.025 Export Citation

Improvement single-wall carbon nanotubes (SWCNTs) based on functionalizing with monomers 2-hydroxyethylmethacryate (HEMA) and N-vinylpyrrolidone (NVP) for pharmaceutical applications as cancer therapy

Fatemeh Abbaszadeh, Omid Moradi^†, Mehdi Norouzi¹, and Omid Sabzevari²

Department of Chemistry, Shahre Qods Branch, Islamic Azad University, Shahre Qods, Tehran, Iran
¹Department of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
²Department of Toxicology and Pharmacology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

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The functionalized carbon nanotubes play significant roles in the fields such as preparation of composite materials and biological technologies. This paper explains the covalent functionalization of single-wall carbon nanotubes (SWCNTs) with biomedical important monomers, 2-hydroxyethylmethacryate (HEMA) and N-vinylpyrrolidone (NVP) by chemical grafting of HEMA and PVP monomers via free radical polymerization. To get carboxylic acid functionalized SWCNTs, first the nanotubes were oxidized with a mixture of nitric acid and sulfuric acid (1:3). Then, the binding of HEMA and NVP onto the surface of SWCNTs was performed by chemical functionalization of HEMA, NVP with acid chloride-bound carbon nanotube by esterification reaction. These results were confirmed by FT-IR and SEM. The cell culture experiments conducted for pharmaceutical applications were used as cancer therapy.

Keywords:SWCNTs;HEMA;NVP;AIBN;Functionalization;Drug delivery;Cell culture;Hydrogels;Cell culture

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[3] Kakade B, Patil S, Sathe S, Gokhale S, Pillai V, J. Chem. Sci., 120, 599 (2008)

[4] Najafi F, J. Nanostruct. Chem., 3, 23 (2013)

[5] Wang F, Deng KJ, Zhou L, Zhao JB, Ke XH, Wen LL, J. Inorg. Organomet. Polym., 22, 1182 (2012)

[6] Manivannan S, Jeong IO, Ryu JH, Lee CS, Kim KS, Jang J, Park KC, J. Mater. Sci. -Mater. Electron., 20, 223 (2009)

[7] Vahdati AR, Sadeghi B, J. Nanostruct. Chem., 3, 7 (2013)

[8] Ogoshi T, Saito T, Yamagishi TA, Nakamoto Y, Carbon, 47, 117 (2009)

[9] Ogoshi T, Saito T, Yamagishi T, Nakamoto Y, Carbon, 47, 117 (2009)

[10] Zu SZ, Sun XX, Zhou D, Han BHJ, Carbon, 49, 5339 (2011)

[11] Pino AP, Gyorgy E, Cabana L, Ballesteros B, Tobias G, Carbon, 50, 4450 (2012)

[12] Thompson BC, Moulton SE, Gilmore KJ, Higgins MJ, Whitten PG, Wallace GG, Carbon, 47, 1282 (2009)

[13] Li H, Wang DQ, Liu BL, Gao LZ, Colloids Surf. B: Biointerfaces, 33, 85 (2004)

[14] Blighe FM, Young K, Vilatela JJ, Windle AH, Kinloch IA, Deng LB, Young RJ, Coleman JN, Adv. Funct. Mater., 21(2), 364 (2011)

[15] Spitalskya Z, Tasisb D, Papagelis K, Galiotis C, Prog. Polym. Sci, 35, 357 (2010)

[16] Sirousazar M, Kokabi MZ, Hassan M, Bahramian AR, J. Macromol. Sci.-Phys., 51, 1335 (2012)

[17] Montazeri A, Naghdabadi R, J. Appl. Polym. Sci., 117, 361 (2009)

[18] Zhang L, Rakotondradany F, Myles AJ, Fenniri H, Webster TJ, Biomaterials, 30, 1309 (2009)

[19] Im JS, Yun J, Lim YM, Kim HI, Lee YS, Acta Biomater., 6, 102 (2010)

[20] Breuer O, Sundaraj U, Soc. Plast. Eng., 25, 630 (2004)

[21] Xu FJ, Yang WT, Prog. Polym. Sci, 36, 1099 (2011)

[22] Rodrigues AA, Batista NA, Bavaresco VP, Baranauskas V, Ceragioli HJ, Peterlevitz AC, Santos AR, Belangero WD, Carbon, 50, 450 (2012)

[23] El-Sherbiny IM, Reicha FM, J. Nanostruct. Chem., 3, 8 (2013)

[24] Rao JP, Geckeler KE, Prog. Polym. Sci, 36, 887 (2011)

[25] Lee SG, Brunello GF, Jang SS, Lee JH, Bucknall DG, J. Phys. Chem. B, 113(19), 6604 (2009)

[26] Kobayashi Y, Morimoto H, Nakagawa T, Kubota Y, Gonda K, Ohuchi N, J. Nanostruct. Chem., 3, 11 (2013)

[27] De Guzman M, Liu PY, Chen JT, Tung KL, Lee KR, Lai JY, J. Membr. Sci., 378(1-2), 503 (2011)

[28] Stamatialis DF, Papenburg BJ, Girones M, Saiful S, Bettahalli SNM, Schmitmeier S, Wessling M, J. Membr. Sci., 308(1-2), 1 (2008)

[29] Huang CF, Kuo SW, Lin FJ, Wang CF, Hung CJ, Chang FC, Polymer, 4, 7060 (2006)

[30] Barve R, Chaughule R, J. Nanostruct. Chem., 3, 18 (2013)

[31] Oral A, Tasdelen MA, Demirel AL, Yagci Y, Polymer, 50(16), 3905 (2009)

[32] Oh JK, Drumright R, Siegwart DJ, Matyjaszewski K, Prog. Polym. Sci, 33, 448 (2008)

[33] Kumar NA, Ganapathy HS, Kim JS, Jeong YS, Jeong YT, Eur. Polym. J., 44, 579 (2008)

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[35] Hesabi M, Hesabi M, J. Nanostruct. Chem., 3, 22 (2013)