Cellular protective effects of dehydroeffusol isolated from Juncus effusus L. and the mechanisms underlying these effects

Soo Nam Park; Doo Hyun Won; Jun Pil Hwang; Saet Byeol Han

Journal of Industrial and Engineering Chemistry, Vol.20, No.5, 3046-3052, September, 2014

DOI10.1016/j.jiec.2013.11.041 Export Citation

Cellular protective effects of dehydroeffusol isolated from Juncus effusus L. and the mechanisms underlying these effects

Soo Nam Park^†, Doo Hyun Won, Jun Pil Hwang, and Saet Byeol Han

Department of Fine Chemistry, Nanobiocosmetic Laboratory, and Cosmetic R&D Center, Seoul National University of Science and Technology, 232 Gongneung-ro, Nowon-gu, Seoul 139-743, Republic of Korea

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The purpose of this study was to identify the substance responsible for significant cellular protective effect of the extract from Juncus effusus L. on the photohemolysis of erythrocyte and to investigate the mechanism underlying this effect. The single substance was identified as ‘‘dehydroeffusol’’. To investigate the mechanism, cellular protective effect, singlet oxygen quenching rate constant, free radical and reactive oxygen species (ROS) scavenging activity and erythrocyte membrane penetration efficiency were tested. The results showed that ROS incidentally produced in the Type II reaction is the main reason for photohemolysis and that erythrocyte membrane penetration ability is crucial to cell protection.

Keywords:Juncus effusus L.;Cellular protective effect;Dehydroeffusol;Skin-aging;Mechanism

[References]

Yaar M, Gilchrest BA, Br. J. Dermatol., 157, 874 (2007)
Harman D, Mutat. Res., 275, 257 (1992)
Ashok BT, Ali R, Exp. Gerontol., 34, 293 (1999)
Wickens AP, Resp. Physiol., 128, 379 (2001)
Lee HJ, Lim GN, Park MA, Park SN, J. Microbiol. Biotechnol., 39, 63 (2011)
Kim SY, Won DH, Lim MS, Park SN, Korean J. Pharmacogn., 41, 264 (2010)
Kohen R, Biomed. Pharmacother., 53, 181 (1999)
Valentina S, Soren M, Britta M, Sascha B, AlexanderB, Jurgen B, Marina J, Mech. Ageing Dev., 131, 48 (2010)
Valle LG, Biomed. Aging Pathol., 1, 1 (2011)
Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M, Chemico-Biol. Interact., 160, 1 (2006)
Park SN, J. Soc. Cosmet. Sci. Korea, 23, 75 (1997)
Park SN, Korean J. Food Sci. Technol., 35, 510 (2003)
Montana MP, Massad WA, Criado S, Biasutti A, Garcia NA, Photochem. Photobiol., 86, 827 (2010)
Lee DS, Lim MS, Kwan SS, Kim SY, Park SN, Appl. Chem. Eng., 23(1), 93 (2012)
Park SN, Master Dissertation, Seoul National University, 1984.
Slater TF, Biochem. J., 222, 1 (1984)
Oh SI, Korean J. Gerontol., 12, 1 (2002)
Kim SI, Ahn YJ, Kim EH, Park SN, J. Soc. Cosmet. Sci. Korea, 35, 159 (2009)
Masaki H, Sakaki S, Atsumi T, Sakurai H, Biol. Pharm. Bull., 18, 162 (1995)
Choi CH, Won DH, Hwang JP, Park SN, J. Soc. Cosmet. Sci. Korea, 38, 275 (2012)
Choi CH, Master Dissertation, Seoul National University of Science and Technology, Seoul, Korea, 2010.
Kim JE, Park CH, Oh DS, Lee SY, Jang SH, Hong JY, Min HJ, Park SA, Won DH, Park SN, J. Soc. Cosmet. Sci. Korea, 37, 357 (2011)

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[2] Harman D, Mutat. Res., 275, 257 (1992)

[3] Ashok BT, Ali R, Exp. Gerontol., 34, 293 (1999)

[4] Wickens AP, Resp. Physiol., 128, 379 (2001)

[5] Lee HJ, Lim GN, Park MA, Park SN, J. Microbiol. Biotechnol., 39, 63 (2011)

[6] Kim SY, Won DH, Lim MS, Park SN, Korean J. Pharmacogn., 41, 264 (2010)

[7] Kohen R, Biomed. Pharmacother., 53, 181 (1999)

[8] Valentina S, Soren M, Britta M, Sascha B, AlexanderB, Jurgen B, Marina J, Mech. Ageing Dev., 131, 48 (2010)

[9] Valle LG, Biomed. Aging Pathol., 1, 1 (2011)

[10] Valko M, Rhodes CJ, Moncol J, Izakovic M, Mazur M, Chemico-Biol. Interact., 160, 1 (2006)

[11] Park SN, J. Soc. Cosmet. Sci. Korea, 23, 75 (1997)

[12] Park SN, Korean J. Food Sci. Technol., 35, 510 (2003)

[13] Montana MP, Massad WA, Criado S, Biasutti A, Garcia NA, Photochem. Photobiol., 86, 827 (2010)

[14] Lee DS, Lim MS, Kwan SS, Kim SY, Park SN, Appl. Chem. Eng., 23(1), 93 (2012)

[15] Park SN, Master Dissertation, Seoul National University, 1984.

[16] Slater TF, Biochem. J., 222, 1 (1984)

[17] Oh SI, Korean J. Gerontol., 12, 1 (2002)

[18] Kim SI, Ahn YJ, Kim EH, Park SN, J. Soc. Cosmet. Sci. Korea, 35, 159 (2009)

[19] Masaki H, Sakaki S, Atsumi T, Sakurai H, Biol. Pharm. Bull., 18, 162 (1995)

[20] Choi CH, Won DH, Hwang JP, Park SN, J. Soc. Cosmet. Sci. Korea, 38, 275 (2012)

[21] Choi CH, Master Dissertation, Seoul National University of Science and Technology, Seoul, Korea, 2010.

[22] Kim JE, Park CH, Oh DS, Lee SY, Jang SH, Hong JY, Min HJ, Park SA, Won DH, Park SN, J. Soc. Cosmet. Sci. Korea, 37, 357 (2011)