The solubilities of L-glutamine in mixed solvents (ethanol + water, acetone + water) were determined at temperatures between 278 K and 313 K. The solubilities of L-glutamine in mixed solvents (water + ethanol, water + acetone) are a function of temperature, increasing with an increase in temperature. Pure water has a high dissolving power. The experimental data were correlated with the Apelblat model. The calculated values of Apelblat model were found to show a fine representation of the experimental data. Then the dissolution enthalpy and entropy of L-glutamine were predicted from the solubility data using van't Hoff equation. The dissolution enthalpy and entropy of L-glutamine in water predicted from the solubility data is less than that in mixed solvents. (C) 2013 Elsevier B.V. All rights reserved.