Molecular imaging in the aid of drug delivery technology

Yong Woo Cho; Kwangmyeung Kim; Kinam Park; Ick Chan Kwon

Macromolecular Research, Vol.22, No.9, 926-931, September, 2014

DOI10.1007/s13233-014-2127-5 Export Citation

Molecular imaging in the aid of drug delivery technology

Yong Woo Cho^{1, 2}, Kwangmyeung Kim^{1, 3}, Kinam Park⁴, and Ick Chan Kwon^{1, 5, †}

¹Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology (KIST), Seoul, 136-791, Korea
²Department of Chemical Engineering, Hanyang University, Gyeonggi, 426-791, Korea
³, Korea
⁴Departments of Biomedical Engineering and Pharmaceutics, Purdue University, West Lafayette, IN, 47907, USA
⁵KU-KIST School, Korea University, Seoul, 136-701, Korea

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Molecular imaging aims to visualize biological processes in a living system at a molecular or cellular level while drug delivery systems (DDS) aim to deliver drugs to specific targets of tissues or organs at a controlled rate. Molecular imaging and DDS, seemingly two different subjects, however, are not completely separate. They share overlapped conceptual and technological spectra. To visualize molecular events in body molecular imaging requires delivery of imaging probes to specific targets, which has been the main technology developed in DDS for decades. Simply replacing drugs in targeted therapeutic DDS with imaging probes turns the whole system to targeted imaging system for diagnosis of diseases. Integrating imaging probes into therapeutic DDS is a starting point for theragnotics, therapy, and diagnosis performed simultaneously with one agent. Key DDS technologies applied to molecular imaging have played an important role in advances of molecular imaging. We here briefly discuss molecular imaging in the aid of drug delivery technology, with an emphasis on theragnotics of tumors.

Keywords:molecular imaging;drug delivery system;theragnostics;tumor;nanomedicine

[References]

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Jee JP, Na JH, Lee S, Kim SH, Choi K, Yeo Y, Kwon IC, Curr. Opin. Solid State Mater. Sci., 16, 333 (2012)
Park JH, Saravanakumar G, Kim K, Kwon IC, Adv. Drug Deliv. Rev., 62, 28 (2010)
Kim SE, Kwon IC, Song HR, Park K, Macromol. Res., 20(11), 1109 (2012)
Matsumura Y, Maeda H, Cancer Res., 46, 6387 (1986)
Kim JH, Kim YS, Kim S, Park JH, Kim K, Choi K, Chung H, Jeong SY, Park RW, Kim IS, Kwon IC, J. Control. Release, 111, 228 (2006)
Yhee JY, Koo H, Lee DE, Choi K, Kwon IC, Kim K, Adv. Polym. Sci., 243, 139 (2011)
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Duncan R, Kopeckova-Rejmanova P, Strohalm J, Hume I, Cable HC, Pohl J, Lloyd JB, Kopecek J, Br. J. Cancer, 55, 165 (1987)
Kim K, Lee M, Park H, Kim JH, Kim S, Chung H, Choi K, Kim IS, Seong BL, Kwon IC, J. Am. Chem. Soc., 128(11), 3490 (2006)

[Referenced By]

[Related Articles]

[1] Herschman HR, Science, 302, 605 (2003)

[2] Yamamoto Y, Ono Y, Aga F, Kawai N, Kudomi N, Nishiyama Y, J. Nucl. Med., 53, 1911 (2012)

[3] Chen X, Park R, Tohme M, Shahinian AH, Bading JR, Conti PS, Bioconjug. Chem., 15(1), 41 (2004)

[4] Mitra A, Mulholland J, Nan A, McNeill E, Ghandehari H, Line BR, J. Control. Release, 102, 191 (2005)

[5] Cai W, Shin DW, Chen K, Gheysens O, Cao Q, Wang SX, Gambhir SS, Chen X, Nano Lett., 6, 669 (2006)

[6] Kim K, Kim JH, Kim S, Chung H, Choi K, Kwon IC, Park JH, Kim YS, Park RW, Kim IS, Jeong YS, Macromol. Res., 13(3), 167 (2005)

[7] Jee JP, Na JH, Lee S, Kim SH, Choi K, Yeo Y, Kwon IC, Curr. Opin. Solid State Mater. Sci., 16, 333 (2012)

[8] Park JH, Saravanakumar G, Kim K, Kwon IC, Adv. Drug Deliv. Rev., 62, 28 (2010)

[9] Kim SE, Kwon IC, Song HR, Park K, Macromol. Res., 20(11), 1109 (2012)

[10] Matsumura Y, Maeda H, Cancer Res., 46, 6387 (1986)

[11] Kim JH, Kim YS, Kim S, Park JH, Kim K, Choi K, Chung H, Jeong SY, Park RW, Kim IS, Kwon IC, J. Control. Release, 111, 228 (2006)

[12] Yhee JY, Koo H, Lee DE, Choi K, Kwon IC, Kim K, Adv. Polym. Sci., 243, 139 (2011)

[13] Weissleder R, Tung CH, Mahmood U, Bogdanov A, Nat. Biotechnol., 17, 375 (1999)

[14] Kopecek J, Rejmanova P, Chytry V, Makromol. Chem., 182, 799 (1981)

[15] Rejmanova P, Kopecek J, Duncan R, Lloyd JB, Biomaterials, 6, 45 (1985)

[16] Duncan R, Kopeckova-Rejmanova P, Strohalm J, Hume I, Cable HC, Pohl J, Lloyd JB, Kopecek J, Br. J. Cancer, 55, 165 (1987)

[17] Kim K, Lee M, Park H, Kim JH, Kim S, Chung H, Choi K, Kim IS, Seong BL, Kwon IC, J. Am. Chem. Soc., 128(11), 3490 (2006)