화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.22, No.9, 1032-1041, September, 2014
DOI10.1007/s13233-014-2140-8  Export Citation
Effect of magnesium hydroxide nanoparticles with rod and plate shape on mechanical and biological properties of poly(L-lactide) composites
Chang Hun Kum1, 2, Seong Ho Seo1, 3, Sung Nam Kang1, 4, Bang Ju Park5, Dong June Ahn6, Yoon Ki Joung1, 4, †, and Dong Keun Han1, 4, †
  • 1Center for Biomaterials, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul, 136-791, Korea
  • 2Department of Chemical and Biological Engineering, Korea University, Seoul, 136-701, Korea
  • 3, Korea
  • 4Department of Biomedical Engineering, Korea University of Science and Technology, Daejeon, 305-350, Korea
  • 5Department of Electronic Engineering and Institute of Gachon Fusion Technology, Gachon University, Gyeonggi, 461-701, Korea
  • 6Department of Chemical and Biological Engineering, University, Seoul, 136-701, Korea
E-mail:,
Two kinds of magnesium hydroxide (Mg(OH)2) rods (Mg-Rod, 150 and 350 nm in size) and plates (Mg-PL, 60 and 300 nm) were prepared, and blended with poly(L-lactide) (PLLA) to obtain PLLA/Mg(OH)2 composites to investigate the effect of the shape and size of Mg(OH)2 particles. The structure, morphology, pH change, thermal and mechanical properties, cytotoxicity, and inflammation of Mg(OH)2 control and PLLA/Mg(OH)2 composites were evaluated. PLLA/Mg-Rod150 (30%) composite showed a 50% higher tensile strength and a 45% improved modulus as compared with PLLA/Mg-PL300 30% composite. Although Mg-Rods displayed similar cell viability (above 80%) as compared to Mg-PLs, the expression levels of TNF-α from Mg-PL60 gradually increased with increasing concentrations from 1 to 300 μg. This indicates that Mg-PL60 had a potential cytotoxicity due to endocytosis. In addition, the byproduct of PLLA/Mg-Rods composite was more effectively neutralized than that of the PLLA/Mg-PLs composite, but cell viability and the expression levels of TNF-α were similar. Therefore, the use of our PLLA/Mg-Rod composite system would be a promising strategy to prevent the current fatal problems in biomedical applications including biodegradable implants such as stents.
Keywords:poly(L-lactide);magnesium hydroxide;shape;mechanical property;inflammation
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