플라즈마 중합 처리된 중공사 막의 혈액 적합성

권오성; 이삼철; O.S. Kwon; S.C. Lee

Korean Journal of Materials Research, Vol.15, No.8, 521-527, August, 2005

DOI10.3740/MRSK.2005.15.8.521 Export Citation

플라즈마 중합 처리된 중공사 막의 혈액 적합성

Blood Compatibility of Hollow Fiber Membranes Treated with Plasma Polymerization

권오성, 이삼철^{1, †}

전북대학교 신소재공학부
¹한려대학교 신소재공학과

O.S. Kwon, and S.C. Lee^{1, †}

School of Advanced Materials Engineering, Chonbouk National University, Chonju, 561-756, Korea
¹Dept. of Advanced Materials Engineering, Hanlyo University, Kawangyang, 545-704, Korea

E-mail:

Surface modification of polypropylene hollow fiber membranes was peformed in order to develop blood-compatible biomaterials for use in the blood contacting and oxygenation membranes of a lung-assist device(LAD). Blood compatibility was determined by using anticoagulation blood and evaluating formation of blood clots on their surfaces as well as activation of plasma coagulation cascade, platelet adhesion, and aggregation. It was verified that the number of platelets on the silicone coated fibers was significantly lower than those on polypropylene. It was also found that the polypropylene hollow fiber membranes using plasma treatment exhibited suppression of complement activation in blood compatibility test.

Keywords:blood compatibility;polypropylene hollow fiber membranes;plasma polymerization

[References]

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[1] Hattler BG, Jhonson PC, Sawzik PJ, Saffer FD, Klain M, Lund LW, Reeder GD, Walters FR, Goode JS, Borovetz HS, ASAIO J., 38, M322 (1992)

[2] Garber BG, Critical Care Medicine, 24(4), 687 (1996)

[3] Conrad SA, Eggerstedt JM, Morris VF, Romero MD, Chest, 107(6), 1689 (1995)

[4] Hooker TP, Thomas P, Hammond MD, Allen S, J. Am. Osteopathic Assoc., 92(7), 886 (1992)

[5] Eash HJ, Jones HM, Hattler BG, Federspiel WJ, ASAIO J., 50, 491 (2004)

[6] Zimmermann AK, Aebert H, Freitag M, Husseini M, Ziemer G, Wendel HP, ASAIO J., 50, 193 (2004)

[7] Wang D, Alpard SK, Savage C, Yamani HN, Deyo DJ, Nemser S, Zwischenberger JB, ASAIO J., 49, 673 (2003)

[8] Mortensen JD, Trans. Am. Soc. Artif. Int. Org., 33, 570 (1987)

[9] Bagley B, Bagley A, Henrie J, Froerer C, Brohamer J, Burkart J, Mortensen JD, ASAIO Transactions, 37, M413 (1991)

[10] Mortensen JD, U. S. Patent, 4, 583, 969, April (1986) (1986)

[11] Hattler BG, Reeder GD, Sawzik PJ, Lund LW, Walters FR, Shah AS, Rawleigh J, Goode JS, Klain M, Borovetz H, Artif. Organs, 18(11), 806 (1994)

[12] Imai Y, Nose Y, J. Biomed. Mater. Res., 6, 165 (1972)

[13] Lee RI, White PD, J. Am. Med. Sci., 145, 495 (1913)

[14] Han DS, Jeong SY, Kim YH, Min BG, Cho HI, J. Biomed. Mater. Res., 25, 561 (1991)

[15] Ito Y, Imanishi Y, CRC Critical Reviews in Biocompatibility, 5, 45 (1989)

[16] Ito Y, Iwata K, Hang IK, Sisido M, Imanishi Y, Int. T. Biol. Macromol, 10, 169 (1988)