Hydrogel lenses functionalized with polysaccharide for reduction of protein adsorption

Ho-Joong Kim; Geun-Chang Ryu; Keun-Seung Jeong; Jin Jun

Macromolecular Research, Vol.23, No.1, 74-78, January, 2015

DOI10.1007/s13233-015-3009-1 Export Citation

Hydrogel lenses functionalized with polysaccharide for reduction of protein adsorption

Ho-Joong Kim, Geun-Chang Ryu¹, Keun-Seung Jeong¹, and Jin Jun^{1, †}

Department of Chemistry, Chosun University, Gwangju, 501-759, Korea
¹Department of Optometry and Optic Science, Dongshin University, Naju, Jeonnam, 520-714, Korea

E-mail:

The synthesis and characterization of a series of poly(2-hydroxyethyl methacrylate) (pHEMA)-based hydrogel lenses functionalized with polysaccharides are described. The functionalization of hydrogels with hyaluronic acid and alginic acid was performed by construction of an interpenetrating polymer network (IPN) structure consisting of HEMA-backbones and polysaccharide networks. The surface protein adsorption, water content, optical transparency, and surface properties of the hydrogels were investigated. The hydrogels exhibited transmittance of over 90% and water content of over 50%. Notably, the amount of protein adsorbed on the polysaccharide-modified hydrogels decreased by more than 50% as compared to that in the case of the control hydrogel. These results suggest that hydrogels modified with polysaccharide may offer intriguing potential for ophthalmic biomaterials as well as protein resistant coating materials.

Keywords:hydrogel;polysaccharide;protein adsorption;hyaluronic acid;contact lens

[References]

Doerte L, Lyndon J, Cont. Lens Anterior Eye, 31, 179 (2008)
Riley C, Young G, Chalmers R, Eye Contact Lens, 32, 281 (2006)
Doerte L, Lyndon J, Cont. Lens Anterior Eye, 35, 53 (2012)
Lorda MS, Stenzelb MH, Simmonsa A, Milthorpe BK, Biomaterials, 27, 1341 (2006)
Willcox MDP, Hume EBH, Aliwarga Y, Kumar N, Cole N, J. Appl. Microbiol., 105(6), 1817 (2008)
Chan GY, Hughes TC, McLean KM, McFarland GA, Nguyen X, Wilkie JS, Biomaterials, 27, 1287 (2006)
Scott EA, Nichols MD, Cordova LH, George BJ, Jun YS, Elbert DL, Biomaterials, 29, 4481 (2008)
Heo SB, Jeon YS, Kim SI, Kim SH, Kim JH, Macromol. Res., 22(2), 203 (2014)
Thissen H, Gengenbach T, du Toit R, Sweeney DF, Kingshott P, Griesser HJ, Meagher L, Biomaterials, 31, 5510 (2010)
Rahman MM, Chun HH, Park H, Macromol. Res., 19(1), 8 (2011)
Shimizu T, Goda T, Minoura N, Takai M, Ishihara K, Biomaterials, 31, 3274 (2010)
Goda T, Matsuno R, Konno T, Takai M, Ishihara K, J. Biomed. Mater. Res. B: Appl. Biomater., 89, 184 (2009)
Cao XY, Pettit ME, Conlan SL, Wagner W, Ho AD, Clare AS, Callow JA, Callow ME, Grunze M, Rosenhahn A, Biomacromolecules, 10(4), 907 (2009)
Meyers SR, Grinstaff MW, Chem. Rev., 112(3), 1615 (2012)
Beeka MV, Jones L, Sheardown H, Biomaterials, 29, 780 (2008)
Beeka MV, Weeks A, Jones L, Sheardown H, J. Biomater. Sci. Polym. Ed., 19, 1425 (2008)
Scheuer CA, Fridman KM, Barniak VL, Burke SE, Venkatesh S, Cont. Lens Anterior Eye, 33, 2 (2010)
Liu Y, Duan LJ, Kim MJ, Kim JH, Chung DJ, Macromol. Res., 22(3), 240 (2014)
Benhabbour SR, Sheardown H, Adronov A, Macromolecules, 41(13), 4817 (2008)
Perrino C, Lee S, Choi SW, Maruyama A, Spencer ND, Langmuir, 24(16), 8850 (2008)
Rana D, Matsuura T, Chem. Rev., 110(4), 2448 (2010)
Reddy PRS, Rao KM, Rao KSVK, Shchipunov Y, Ha CS, Macromol. Res., 22(8), 832 (2014)
Liu Z, Lu A, Yang Z, Luo Y, Macromol. Res., 21(4), 376 (2013)
Weeks A, Luensmann D, Boone A, Jone L, Sheardown H, J. Biomater. Appl., 27, 423 (2012)
Garrett Q, Chatelier RC, Griesser HJ, Milthorpe BK, Biomaterials, 19, 2175 (1998)
Garrett Q, Garrett RW, Miltborpe1 BK, Invest. Ophthalmol. Vis. Sci., 40, 897 (1999)

[Referenced By]

[1] Doerte L, Lyndon J, Cont. Lens Anterior Eye, 31, 179 (2008)

[2] Riley C, Young G, Chalmers R, Eye Contact Lens, 32, 281 (2006)

[3] Doerte L, Lyndon J, Cont. Lens Anterior Eye, 35, 53 (2012)

[4] Lorda MS, Stenzelb MH, Simmonsa A, Milthorpe BK, Biomaterials, 27, 1341 (2006)

[5] Willcox MDP, Hume EBH, Aliwarga Y, Kumar N, Cole N, J. Appl. Microbiol., 105(6), 1817 (2008)

[6] Chan GY, Hughes TC, McLean KM, McFarland GA, Nguyen X, Wilkie JS, Biomaterials, 27, 1287 (2006)

[7] Scott EA, Nichols MD, Cordova LH, George BJ, Jun YS, Elbert DL, Biomaterials, 29, 4481 (2008)

[8] Heo SB, Jeon YS, Kim SI, Kim SH, Kim JH, Macromol. Res., 22(2), 203 (2014)

[9] Thissen H, Gengenbach T, du Toit R, Sweeney DF, Kingshott P, Griesser HJ, Meagher L, Biomaterials, 31, 5510 (2010)

[10] Rahman MM, Chun HH, Park H, Macromol. Res., 19(1), 8 (2011)

[11] Shimizu T, Goda T, Minoura N, Takai M, Ishihara K, Biomaterials, 31, 3274 (2010)

[12] Goda T, Matsuno R, Konno T, Takai M, Ishihara K, J. Biomed. Mater. Res. B: Appl. Biomater., 89, 184 (2009)

[13] Cao XY, Pettit ME, Conlan SL, Wagner W, Ho AD, Clare AS, Callow JA, Callow ME, Grunze M, Rosenhahn A, Biomacromolecules, 10(4), 907 (2009)

[14] Meyers SR, Grinstaff MW, Chem. Rev., 112(3), 1615 (2012)

[15] Beeka MV, Jones L, Sheardown H, Biomaterials, 29, 780 (2008)

[16] Beeka MV, Weeks A, Jones L, Sheardown H, J. Biomater. Sci. Polym. Ed., 19, 1425 (2008)

[17] Scheuer CA, Fridman KM, Barniak VL, Burke SE, Venkatesh S, Cont. Lens Anterior Eye, 33, 2 (2010)

[18] Liu Y, Duan LJ, Kim MJ, Kim JH, Chung DJ, Macromol. Res., 22(3), 240 (2014)

[19] Benhabbour SR, Sheardown H, Adronov A, Macromolecules, 41(13), 4817 (2008)

[20] Perrino C, Lee S, Choi SW, Maruyama A, Spencer ND, Langmuir, 24(16), 8850 (2008)

[21] Rana D, Matsuura T, Chem. Rev., 110(4), 2448 (2010)

[22] Reddy PRS, Rao KM, Rao KSVK, Shchipunov Y, Ha CS, Macromol. Res., 22(8), 832 (2014)

[23] Liu Z, Lu A, Yang Z, Luo Y, Macromol. Res., 21(4), 376 (2013)

[24] Weeks A, Luensmann D, Boone A, Jone L, Sheardown H, J. Biomater. Appl., 27, 423 (2012)

[25] Garrett Q, Chatelier RC, Griesser HJ, Milthorpe BK, Biomaterials, 19, 2175 (1998)

[26] Garrett Q, Garrett RW, Miltborpe1 BK, Invest. Ophthalmol. Vis. Sci., 40, 897 (1999)