Given the need to rein in the rise in the global average temperature, decarbonizing the electricity sector, which accounts for nearly 50% of global greenhouse gas (GHG) emissions, is crucial. The suitability of nuclear power as a base-load technology and its relatively negligible GHG emissions raised expectations of a nuclear renaissance, until the Fukushima disaster brought discussions about nuclear power's potential to a standstill. However, completely ruling out nuclear may not be sustainable owing to the realities of rising energy demand, climate change considerations, and the need for reliable base-load supply technology, especially in the case of fast growing economies in the Association of South East Asian Nations (ASEAN). The Fukushima disaster was a wake-up call for both governments and the nuclear industry. Led by the International Atomic Energy Agency, the more advanced economies conducted stringent reviews of safety standards and emergency response procedures in the event of a catastrophe. Meanwhile the industry responded with strong commitments towards "Fukushima proof" designs, alongside other advancements towards "safer" fission power. In the ASEAN context, we argue in this paper that in addition to the economic advantage, nuclear power can help address the twin objectives of energy security and mitigating climate change effects. In ASEAN, there is still a strong momentum towards nuclear power development due to strategic considerations. In this paper, we reviewed in a holistic approach the various factors influencing decision making on nuclear power. Using ASEAN as a case study, we argue that nuclear power remains an important option and should be taken up rapidly if decarbonizing electricity generation is a grave concern. We also provide some recommendations towards the "safer nuclear" for ASEAN at the end of this paper. (C) 2014 Elsevier Ltd. All rights reserved.