This paper deals with the data-driven design of observer-based fault detection and control systems. We first introduce the definitions of the data-driven forms of kernel and image representations. It is followed by the study of their identification. In the context of a fault-tolerant architecture, the design of observer-based fault detection, feed-forward and feedback control systems are addressed based on the data-driven realization of the kernel and image representations. Finally, the main results are demonstrated on the laboratory continuous stirred tank heater (CSTH) system. (C) 2014 Elsevier Ltd. All rights reserved.