Biochemical and Biophysical Research Communications, Vol.455, No.3-4, 190-193, 2014
Cyanide does more to inhibit heme enzymes, than merely serving as an active-site ligand
The toxicity of cyanide is hitherto attributed to its ability to bind to heme proteins' active site and thereby inhibit their activity. It is shown herein that the long-held interpretation is inadequate to explain several observations in heme-enzyme reaction systems. Generation of cyanide-based diffusible radicals in heme-enzyme reaction milieu could shunt electron transfers (by non-active site processes), and thus be detrimental to the efficiency of oxidative outcomes. (C) 2014 Elsevier Inc. All rights reserved.