This study evaluates the production of biodiesel and ethanol from spent coffee grounds (SCG). The extraction of oil from SCG, biodiesel production and ethanol production processes were studied. The liquid-to-solid ratio and temperature were evaluated in the ultrasound-assisted extraction of the oil from SCG. The highest yield (12%) was obtained using 4 mL g(-1) liquid-to-solid ratio at 60 degrees C for 45 min. The process to produce biodiesel showed a yield of 97% into fatty acid methyl esters (FAME). The highest glucose yield (192 mg g(SCG)(1)) was obtained by hydrolysis with 0.4 mol L-1 sulfuric acid at 121 degrees C for 15 min. The hydrolysate was used as fermentation medium for ethanol production by Saccharomyces cerevisiae obtaining 19.0 g L-1 at 10 h of process of ethanol with a yield of ethanol and productivity of 0.50 g g(-1) and 1.90 g L-1 h(-1), respectively. Spent coffee grounds were considered a potential feedstock for biodiesel and ethanol production. (C) 2014 Elsevier Ltd. All rights reserved.