Results of heat transfer coefficient measurements in an agitated vessel heated or cooled by the liquid media flowing in a helical pipe coil are presented in this paper. The multistage impeller made of two pitched six-blade impellers and adjustable clearance was used in a vessel with conical bottom. The transient method based on measuring the temperature dependency on time and solving the unsteady enthalpy balance was used to determine the heat transfer coefficients between the agitated liquid and the helical pipe coil. The results are summarized by the Nusselt number correlations, which describe the dependency on the impeller Reynolds number. The second part of this paper introduces a theoretical analysis of the flow in the liquid batch near the helical pipe coil. Based on the known pumping capacity of the multistage impeller, the characteristic velocity near the helical pipe coil can be evaluated. This characteristic velocity can be then used to determine the Nusselt number describing the heat transfer in a flow around a cylinder with the same cross-section profile as the helical pipe coil. A clear correlation between this Nusselt number and the integral Nusselt number is presented in this paper and introduces an alternative approach for prediction of heat transfer characteristics on the basis of hydrodynamic parameters describing an agitated system.