Hydrodeoxygenation (HDO) of guaiacol (GUA), has been carried out over gamma-Al2O3, CeO2, SBA-15 supported NiMo catalysts in an autoclave at 250 A degrees C and a hydrogen pressure of 5 MPa. In comparison with NiMo/gamma-Al2O3, both NiMo/CeO2 and NiMo/SBA-15 catalysts showed their higher activities. NiMo/SBA-15 has been found to be the most potential one for HDO of GUA with GUA conversion and HDO degree of 90 and 67.5 %, respectively. The main product was cyclohexane with its yield of 56 mol%. The outstanding activity of this catalyst results from a high dispersion of its active sites on SBA-15 as catalyst support. For CeO2 supported catalyst, some interactions of Ce-Mo can be occurred, leading to an enhancement of its HDO performance.