Conventional process monitoring method based on fast independent component analysis (FastICA) cannot take the ubiquitous measurement noises into account and may exhibit degraded monitoring performance under the adverse effects of themeasurement noises. In this paper, a newprocessmonitoring approach based on noisy time structure ICA (NoisyTSICA) is proposed to solve such problem. A NoisyTSICA algorithm which can consider the measurement noises explicitly is firstly developed to estimate the mixing matrix and extract the independent components (ICs). Subsequently, a monitoring statistic is built to detect process faults on the basis of the recursive kurtosis estimations of the dominant ICs. Lastly, a contribution plot for the monitoring statistic is constructed to identify the fault variables based on the sensitivity analysis. Simulation studies on the continuous stirred tank reactor system demonstrate that the proposed NoisyTSICA-based monitoring method outperforms the conventional FastICA-based monitoring method. (C) 2014 The Chemical Industry and Engineering Society of China, and Chemical Industry Press. All rights reserved.