The objective of this work is the formulation of a multi-scale framework for electrochemically promoted systems. We have constructed a 3-Dimensional, isothermal, solid oxide single pellet, multi-scale framework, which describes the chemical and electrochemical phenomena taking place in a solid oxide single pellet under closed-circuit conditions, while the electrochemically promoted oxidation of CO over Pt/YSZ is used as an illustrative system. The proposed framework combines a 3-D macroscopic model which employs the finite element method (FEM) for the simulation of the charge transport and the electrochemical phenomena taking place in the pellet, and an in-house developed efficient implementation of a 2-D lattice kinetic Monte Carlo method (kMC) for the simulation of the reaction-diffusion micro-processes taking place on the catalytic surface. Comparison between the multiscale framework and a macroscopic model [1] is carried out for several sets of operating conditions. Differences between the steady-state outputs of the two models are presented and discussed. A subsequent parametric study using the multi-scale framework is performed to investigate the effect of the gaseous species partial pressures and of the temperature on the CO2 production rate. (C) 2014 The Authors. Published by Elsevier Ltd.