In this paper a single-phase cascaded Multilevel Inverter (MI) consisting of full NPC bridges for renewable energy systems is investigated. The development of the introduced control strategy is based on the application of Model Predictive Control (MPC) technique meeting the required specifications of the individual voltage level regulation of each separate DC source and neutral point potential balance under unity power factor. Illustrating the effectiveness of the developed controller, two separate PV strings are controlled while being subject to transient phenomena related to asymmetric string conditions in terms of solar radiation and reference voltage variation. The inverter topology of full NPC bridges in cascade allows low current THD factor to be achieved using a simple inductor instead of complicated LCL filters benefiting also from low capacitor banks in the DC-link bus. The proposed MPC performance has been validated by experiments carried out on a cascaded MI topology delivering power from two separate PV system strings. (C) 2014 Elsevier Ltd. All rights reserved.