In the previous work, the multi-scale chemical reaction model was developed by Wang et al. (2014) to consider the impact of the meso-scale structure on reaction performance. This paper incorporates multi-scale heat transfer to further improve the previous multi-scale chemical reaction model. The temperature field in the cluster phase and the dispersed phase is predicted. A cluster structure-dependent (CSD) drag model is used to obtain local structural parameters. By comparison with experimental data, there is a slight improvement on predicted results with consideration of the multi-scale heat transfer. Meanwhile, the inter-phase heat transfer between the cluster phase and the dispersed phase is evaluated. The results indicate that the effect of the inter-phase heat transfer on the temperature field is less significant than the effect of the inter-phase mass transfer on gas components. (C) 2014 Elsevier Ltd. All rights reserved.