Numerical simulation of bubble dynamics in bubble columns with internals is investigated, and the results show that internal solid walls significantly affect bubble behavior. The trajectories of the selected diameter bubbles tend to be rectilinear, and there are rocking and oscillation for small bubbles which are associated with vortex shedding in the bubble wake. Bubble axially elongates and bubble aspect ratio increases with the increase of internals covered cross-sectional area (CSA). Simultaneously, bubble rise velocity is reduced, and it is related with internals covered CSA and pitch type. Moreover, simulation of bubble dynamics in different diameter internals indicates that hydraulic diameter is the key parameter for scale-up of bubble columns with internals. In addition, bubble breakup and turbulence structure are profoundly impacted by the internal solid walls.