Disubstituted carba-closo-dodecaborate anions with one functional group bonded to the cluster carbon atom and one ethynyl group bonded to the antipodal boron atom were synthesized from easily accessible {closo-1-CB11} clusters. [Et4N][1-NC-12-HC C-closo-1-CB11H10] ([Et4N]4b) was prepared starting from Cs[12-Et3SiC C-closo-1-CB11H11] (Cs1c) via salts of the anions [1-HO(O)C-12-HC C-closo-1-CB11H10](-) (2b) and [1-H2N(O)C-12-HC C-closo-1-CB11H10](-) (3b). In a similar reaction sequence [Et4N][1-CN-12-HC C-closo-1-CB11H10] ([Et4N]7b) was obtained from Cs[1-H2N-12-HC C-closo-1CB(11)H(10)] (Cs5b) by formamidation to yield [Et4N][1-H(O)CHN-12-HC C-closo-1-CB11H10] ([Et4N]6b) and successive dehydration. In addition, the synthesis of the isonitrile [Et4N][1-CN-closo-1-CB11H11] ([Et4N]7a) is presented. The {closo-1-CB11 } derivatives were characterized by multinuclear NMR as well as vibrational spectroscopy, mass spectrometry, and elemental analysis. The crystal structures of [Et4N][1-HO(O)C-12-HC C-closo-1-CB11H10] ([Et4N]2b), [Et4N][1-H2N(O)C-12-HC C-closo-1-CB11 H-10] [Et4N]3b), [Et4N] [1-NC-12-HC C-closo-1-CB11H10] ([Et4N]4b), [Et4N] [1-H(O) CHN-12-HC C-closo-1-CB11H10 ([Et4N]6b), [Et4N][1-CN-12-HC C-closo-1-CB11H10] ([Et4N]7b), and K[1-H(O)CHN-closo-1-CB11H11] ([Et4N]6a) were determined. The transmission of electronic effects through the carba-closo-dodecaboron cage was studied based on C-13 NMR spectroscopic data, by results derived from density functional theory calculations, and by a comparison to the data of related benzene and bicydo[2.2.2]octane derivatives.