Inorganic Chemistry, Vol.53, No.19, 10015-10017, 2014
Selective Binding and Reverse Transcription Inhibition of Single-Strand poly(A) RNA by Metal TMPyP Complexes
Ni-, Cu-, and Zn-TMPyP are capable of binding to single-strand poly(A) RNA with high preference and affinity and inhibiting the reverse transcription of RNA by both M-MuLV and HIV-1 reverse transcriptase. With 10 nM azidothymidine, the IC50 value of M-TMPyP could be lowered to 10(-1) mu M order.