This paper presents experimental investigation of the performance of an organic Rankine cycle (ORC) with scroll expander which utilizes renewable, process and waste heats. An ORC test bench is built with a scroll expander-generator unit modified from a refrigeration compressor-electrical drive unit. A detailed experimental investigation within the test bench is performed with the organic working fluid R134a. The results show that scroll expander can effectively be used in low-power ORC to generate mechanical work or electricity from low-temperature thermal sources (e.g. 80-200 degrees C, respectively). The experiments are performed under fixed intake conditions into the expander. The pressure ratio and the load connected to the expander-generator unit were varied. It is found that an optimum pressure ratio and an optimum angular speed co-exist. When operating optimally, the expander's isentropic efficiency is the highest. The optimum angular speed is around 171rad/s which corresponds to a generated voltage of 18.6V. The optimum pressure ratio is about 4. The isentropic efficiency at optimum operation is found in the range of 0.5 to 0.64, depending on the intake conditions. The volumetric efficiency overpasses 0.9 at optimum operation and degrades significantly if the load is increased over the optimum load. A regenerative ORC equipped with the studied expender-generator unit that operates under 120 degrees C heat source and has an air cooled condenser generates 920W net power with efficiencies of 8.5% energetically and 35% exergetically. Copyright (c) 2014 John Wiley & Sons, Ltd.