Ni catalyst supported on MgAl2O4 mixed oxide was prepared by solid state synthesis, co-precipitation and wet impregnation. The mixed oxide support was synthesized by the solid state synthesis at room temperature (MgAl2O4solid) and co-precipitation method (MgAl2O4cop) respectively, followed by wet impregnation for Ni loading. The catalytic performances of these samples were compared in carbon dioxide reforming of methane at 700 degrees C. The results showed that the catalyst Ni/MgAl2O4solid lid with mixed oxide support prepared by solid state synthesis greatly affected the properties and performance of the catalyst. The catalyst Ni/MgAl2O4solid showed higher CO2 and CH4 conversion than the Ni/MgAl2O4cop catalyst with the support prepared by conventional co-precipitation method. In addition, the BET surface area of the catalyst Ni/MgAl2O4solid was three times larger than the catalyst Ni/MgAl2O4cop. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.