The solubilities of l-valine in four binary mixed solvents of water + (ethanol, isopropyl alcohol, N,N-dimethylformamide, acetone) were experimentally measured from 293.15 K to 343.15 K at atmospheric pressure by employing the synthetic method. The experimental data indicate that the solubility of l-valine in the binary mixed solvents increases with the increasing temperature and decreases with the rise of mass concentration (w) of nonaqueous solvent in the binary aqueous solution. The experimental data can be correlated by using the modified Apelblat model, ?h model, and CNIBS/R-K model. The results indicate that the solubility data show agreement with the modified Apelblat model much better than others in the studied binary solvents system. The dissolution enthalpy, dissolution entropy, and molar Gibbs energy of the dissolution of l-valine in the studied binary mixed solvents were then calculated. The experimental data and the correlation equations in this work can be used as essential data and models in the industrial manufacture process of l-valine, especially in antisolvent crystallization.