Solubility of tris(hydroxymethyl)aminomethane (TRIS) in various mass fractions of binary solvent mixtures of methanol and 1-propanol [at (293.2, 298.2, 303.2, 308.2, and 313.2) K] was measured and mathematically represented using the Jouyban-Acree model. The correlated mole fraction solubilities are in good agreement with the corresponding experimental values with an overall mean percentage deviation of 1.7%. Densities of saturated solutions of TRIS in pure methanol and 1-propanol at various temperatures were measured and employed to predict the density of saturated solutions of TRIS in their binary solvent mixtures.