We have developed a technology for producing nonagglomerated nanoparticles by causing collisions of the agglomerates in supersonic flows. To form these nonagglomerated nanoparticles, we conducted three experiments: the collision of agglomerated particles in a supersonic flow with a metal plate, the collision of agglomerated particles contained in two counter-current supersonic flows, and the collision of agglomerated particles in a supersonic flow with dry ice particles. The possibility that these collisions could fragment the agglomerates was investigated by measuring the size distribution of the agglomerates after the collisions using a differential mobility analyzer. Based on the experimental results, we propose that the most efficient technology for the fragmentation of the agglomerates depends on the concentration of the agglomerates. When the concentration is high, two counter-current supersonic flows containing the agglomerates should be used. When the concentrations are low, collision of agglomerates with dry ice particles should be performed.