The fundamental science relating key physical and functional properties of milk powder to plant operating conditions is complex and largely unknown. Consequently this paper takes a data-driven approach to relate the routinely measured plant conditions to one vital function property known as sediment in an industrial-scale powder plant. Data from four consecutive production seasons was examined, and linear regression models based on a chosen set of processing variables were used to predict the sediment values. The average prediction error was well within the range of the uncertainty of the laboratory test. The models could be used to predict the effect of each individual plant variable on the sediment values which could be beneficial in quality optimisation. In addition the choice of the training data set used to compute regression coefficients was studied and the resultant regression models were compared to alternative PLS models built on the same data. (C) 2014 Elsevier Ltd. All rights reserved.