Contaminants that are becoming detected in the environment but are not yet generally regulated or monitored are known collectively as emerging contaminants. In the present study, the occurrence and distribution of 42 emerging organic compounds (EOCs) were investigated in the Yangtze River Estuary and adjacent East China Sea coastal areas. Study compounds were mainly pharmaceuticals, including antibiotics, hormones and sterols, and also included two industrial endocrine disruptors. Samples were analyzed using cross-flow ultrafiltration (CFUF) and,ultra-performance liquid chromatograph-tandem mass spectrometry (UPLC-MS/MS). Results revealed that chloramphenicols, sulfonamides and nonsteroidal anti-inflammatory drugs were the dominant compounds in filtered samples with relatively high concentrations and detection frequencies. EOC levels varied with location, with the highest concentrations being observed around rivers discharging into the estuary, and near sewage outfalls. Colloids that were separated by CFUF tended to be a sink for EOCs with up to 60% being colloid-associated in the water phase. In addition, colloidal properties, including hydrodynamic size, zeta-potential and organic carbon composition, were found to be the main factors controlling the association of EOCs with aquatic colloids. Moreover, these colloidal properties were all significantly related to salinity, indicating the critical role played by increasing salinity in EOCs-colloids interaction in an estuarine system. (C) 2014 Elsevier B.V. All rights reserved.