Pressurized liquid extraction (PLE) of curcuminoids from deflavored turmeric rhizomes was optimized. The rhizomes were initially deflavored by extraction with supercritical CO2. Immediately after SFE, PLE process was performed using ethanol as the solvent and a static extraction time of 20 min, and the independent variables were the temperature (333-353 K) and pressure (10-35 MPa). The results indicate that the optimum extraction temperature and pressure were 333 K and 10 MPa, respectively. PLE required three and six times less extraction time than low-pressure solvent extraction and Soxhlet extraction, respectively, to produce similar extraction yields. The cost of manufacturing (COM) decreased from US$ 94.92 kg(-1) to US$ 88.26 kg(-1) when the capacity of the two-extractor system increased from 0.05 m(3) to 0.5 m(3) and from US$ 94.92 kg(-1) to US$ 17.86 kg(-1) when the cost of the raw materials decreased from US$ 7.91 kg(-1) to US$ 0.85 kg(-1) for a two 0.05 m(3) extractor system. (C) 2014 Elsevier B.V. All rights reserved.