Journal of the American Chemical Society, Vol.136, No.39, 13578-13581, 2014
A New Iron(III)-Salen Catalyst for Enantioselective Conia-ene Carbocyclization
A chiral iron(III)salen complex based on a cis-2,5-diaminobicyclo[2.2.2]octane scaffold catalyzes asymmetric Conia-ene-type cyclization of alpha-functionalized ketones containing an unactivated terminal alkyne and produces an exo-methylenecycloalkane possessing a stereodefined quaternary center.