Shining Light on the Dark Side of Imaging: Excited State Absorption Enhancement of a Bis-styryl BODIPY Photoacoustic Contrast Agent

Frenette M; Hatamimoslehabadi M; Bellinger-Buckley S; Laoui S; La J; Bag S; Mallidi S; Hasan T; Bouma B; Yeleswarapu C; Rochford J

Journal of the American Chemical Society, Vol.136, No.45, 15853-15856, 2014

Frenette M, Hatamimoslehabadi M, Bellinger-Buckley S, Laoui S, La J, Bag S, Mallidi S, Hasan T, Bouma B, Yeleswarapu C, Rochford J

A first approach toward understanding the targeted design of molecular photoacoustic contrast agents (MPACs) is presented. Optical and photoacoustic Z-scan spectroscopy was used to identify how nonlinear (excited-state) absorption contributes to enhancing the photoacoustic emission of the curcuminBF(2) and bis-styryl (MeOPh)(2)BODIPY dyes relative to Cy3.