Production of (S2,3S)-2,3-Dihydro-3-Hydroxy-2-(4-Methoxyphenyl)-1,5-Benzothiazepin-4(5H)-One, a Key Intermediate for Diltiazem Synthesis, by Bakers Yeast-Mediated Reduction

Kometani T; Sakai Y; Matsumae H; Shibatani T; Matsuno R

Journal of Fermentation and Bioengineering, Vol.84, No.3, 195-199, 1997

DOI10.1016/S0922-338X(97)82054-5 Export Citation

Production of (S2,3S)-2,3-Dihydro-3-Hydroxy-2-(4-Methoxyphenyl)-1,5-Benzothiazepin-4(5H)-One, a Key Intermediate for Diltiazem Synthesis, by Bakers Yeast-Mediated Reduction

Kometani T, Sakai Y, Matsumae H, Shibatani T, Matsuno R

Keywords:1;5-BENZOTHIAZEPINE DERIVATIVE CRD-401;3-PHENYLGLYCIDIC ACID ESTER;LARGE-SCALE PREPARATION;ENERGY-SOURCE;ASYMMETRIC HYDROLYSIS;SERRATIA-MARCESCENS;BIOREDUCTION;HYDROCHLORIDE;ETHANOL;LIPASE