A new mathematical model for predicting the contact efficiency of a single collector in the treatment of turbid water is presented in this study. The removal mechanisms applied were interception, diffusion, and sedimentation. In order to obtain the model for the single-collector efficiency, the effect of the density current caused by turbidity and differences in temperature was considered and the impact of multiple-size particles was also included when calculating the respective mechanisms. The sticking coefficient was also calculated, including the effect of the van der Waals attraction energy and electrical double layer forces. The result of the modeling indicated that the predicted efficiency using the developed equation showed good agreement with the experimental values over a wide range of parameters and the increases and decreases in the model performance were simulated very well. The quality of the data was analyzed and this indicated that the experimental work and the developed model showed fairly good agreement.