Solute-solvent interaction of the mixtures containing dipeptides of glycine i.e. glycyl-glycine and glycyl-L-leucine with aqueous solutions of antibacterial drug amoxicillin have been studied with the help of density and speeds of sound measurements at T= (305.15, 310.15, and 315.315) K. Apparent molar properties like apparent molar volume, apparent molar isentropic compression have been calculated from experimental data. Partial molar properties of transfer for dipeptides of glycine from water to aqueous amoxicillin solutions have been calculated from density and speeds of sound data. Limiting apparent molar isentropic compression, pair, and triplet interactions coefficients have also been calculated. The UV absorption studies have also been made in this study. The results have been discussed in terms of competing patterns of interactions prevailing in the solute and solvent. (C) 2014 Elsevier B.V. All rights reserved.