Wear of grinding mill liners and lifters plays a major role in the overall efficiency and economics of mineral processing. Change in the shape of lifters as they wear has a significant influence on grinding efficiency, and the annual cost of maintenance and mill down-time depends on the life of both liners and lifters. The Discrete Element Method (DEM) is a computational method for simulating the dynamics of particle processes. This paper presents an analysis of 3D simulation of a grinding mill carried out using the EDEM software package customised to predict the rate of wear of lifter geometry and to enable progressive updating of worn lifter geometry profiles. A simplified breakage rate model is developed as a tool to correlate liner profile to mill performance. The combination of the prediction of liner profile and grinding rate shows promise to provide a powerful tool for advanced mill liner design - providing a means to balance liner life and mill performance over the life of the liner at the liner design stage. (C) 2011 Elsevier Ltd. All rights reserved.