화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.22, 378-383, February, 2015
DOI10.1016/j.jiec.2014.07.035  Export Citation
Synthesis and biological evaluation of diverse tetrahydrobenzofuran-4-ones as potent antibacterial agents
Likai Xia, Akber Idhayadhulla, Yong Rok Lee†, Sung Hong Kim1, and Young-Jung Wee2
  • School of Chemical Engineering, Yeungnam University, Gyeongsan 712-749, Republic of Korea
  • 1Analysis Research Division, Daegu Center, Korea Basic Science Institute, Daegu 702-701, Republic of Korea
  • 2Department of Food Science and Technology, Yeungnam University, Gyeongsan 712-749, Republic of Korea
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Diverse 3,5,6,7-tetrahydrobenzofuran-4-one derivatives (3a.3n) were synthesized in high yields by ruthenium complex or rhodium complex catalyzed [3 + 2] cycloaddition. The antibacterial activities of these 3,5,6,7-tetrahydrobenzofuran-4-ones were evaluated against Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa, and Enterobacter aerogenes) and Gram-positive bacteria (Bacillus cereus and Staphylococcus aureus). In particular, compound 3b showed the highest antibacterial activity against P.aeruginosa and S. aureus (both MICs: 2 mg/mL). Compound 3l, which has the 2H-pyrano[2,3-b]benzofuran skeleton, exhibited excellent inhibitory activity against B. cereus (MIC: 0.5 mg/mL) as compared with ciprofloxacin (MIC: 2 mg/mL) and ampicillin (MIC: 1 mg/mL).
Keywords:Ruthenium;Rhodium;Diazo compounds;3,5,6,7-Tetrahydrobenzofuran-4-ones;Antibacterial activity
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