화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.23, 109-118, March, 2015
DOI10.1016/j.jiec.2014.08.001  Export Citation
Separation of amoxicillin using trioctylmethylammonium chloride via a hollow fiber supported liquid membrane: Modeling and experimental investigation
Teerapon Pirom, Niti Sunsandee1, Prakorn Ramakul2, Ura Pancharoen†, Kasidit Nootong†, and Natchanun Leepipatpiboon3
  • Department of Chemical Engineering, Faculty of Engineering, Chulalongkorn University, Bangkok 10330, Thailand
  • 1Government Pharmaceutical Organization, Ratchathewi, Bangkok 10400, Thailand
  • 2Department of Chemical Engineering, Faculty of Engineering and Industrial Technology, Silpakorn University, Nakhon Pathom 73000, Thailand
  • 3Chromatography and Separation Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Patumwan, Bangkok 10330, Thailand
E-mail:,
The separation experiments of amoxicillin via hollow fiber supported liquid membrane (HFSLM) were performed under various operating conditions to find the optimal parameters i.e. pH, feed concentration, carrier concentration, and flow rates of feed and stripping solution. Percentages of extraction and recovery of amoxicillin from the feed phase reached 85.21% and 80.34%, respectively. The aqueous-phase mass transfer coefficient (kf) and organic-phase mass transfer coefficient (km) were reported to be 3.57 × 10?2 and 0.70 × 10?2 cm/s, respectively. Furthermore, a mathematical model was developed to predict the concentration of amoxicillin at different times. The results showed promising agreement with experimental data.
Keywords:Separation;Amoxicillin;Hollow fiber supported liquid membrane;Trioctylmethylammonium chloride;Model
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