Alendronate-calcium phosphate hybrid films promoted the osteoblast differentiation and inhibited osteoclastogenic activity

Won-Kyue Yang; Eun-Ju Chang; Woo-Kul Lee

Journal of Industrial and Engineering Chemistry, Vol.27, 391-397, July, 2015

DOI10.1016/j.jiec.2015.01.019 Export Citation

Alendronate-calcium phosphate hybrid films promoted the osteoblast differentiation and inhibited osteoclastogenic activity

Won-Kyue Yang, Eun-Ju Chang¹, and Woo-Kul Lee^†

Department of Chemical Engineering, College of Engineering, Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, South Korea
¹Department of Biomedical Sciences, College of Medicine and Asan Medical Center, University of Ulsan, Ulsan, South Korea

E-mail:

Surface property of biomaterials is a crucial factor determining the biocompatibility of a biomaterial. In this study, we aimed at evaluating the feasibility of alendronate (ALN) and CP hybrid films (CPAs) to promote bone regeneration. Experimental analysis elucidated that ALN incorporation promoted osteoblast proliferation and differentiation, phenotype gene expression, phase shift from differentiation into mineralization, and bone-like nodule formation. Inhibitory effect on the formation of multinucleated osteoclast was substantial. Therefore, the hybrid films can enhance osteogenic responses while inducing anti-osteoclastic effects. We expect the hybrid films can be potentially utilized for the promotion of bone regeneration.

Keywords:Calcium phosphate;Alendronate;Proliferation;Differentiation;Osteoblast;Osteoclast

[References]

Rodan GA, Martin TJ, Science, 289, 1508 (2000)
Boanini E, Torricelli P, Gazzano M, Giardino R, Bigi A, Biomaterials, 29, 790 (2008)
van Beek E, Hoekstra M, van de Ruit M, Lowik C, Papapoulos S, J. Bone Miner. Res., 12, 1875 (1994)
Luckman SP, Hughes DE, Coxon FP, Russell RGG, Rogers MJ, J. Bone Miner. Res., 13(4), 581 (1998)
Dunford JE, Thompsin K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ, J. Pharmacol. Exp. Ther., 296, 235 (2001)
Rodan GA, Fleisch HA, J. Clin. Invest., 97, 2692 (1996)
Im GI, Qureshi SA, Kenney J, Rubash HE, Shanbhag AS, Biomaterials, 25, 4105 (2004)
von Knoch F, Jaquiery C, Kowalsky M, Schaeren S, Alabre C, Martin I, Rubash HE, Shanbhag AS, Biomaterials, 26, 6941 (2005)
Coleman R, Ann. N. Y. Acad., 1218, 3 (2011)
Rogers MJ, Curr. Pharm. Des., 9, 2643 (2003)
Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T, J. Clin. Invest., 104, 1363 (1999)
Giuliani N, Pedrazzoni M, Negri G, Passeri G, Impicciatore M, Girasole G, Bone, 22, 455 (1998)
Bone HG, Hosking D, Devogelaer JP, Tucci JR, Emkey RD, Tonino RP, Rodriguez-Portales J, Downs RW, Gupta J, Santora A, Liberman UA, N. Engl. J. Med., 350, 1189 (2004)
Xiong Y, Yang HJ, Feng J, Shi ZL, Wu LD, J. Int. Med. Res., 37, 407 (2009)
Lourwood DL, Pharmacotherapy, 18, 779 (1998)
Monkkonen J, Simila J, Rogers MJ, Life Sci., 62, L95 (1998)
Elliott SN, McKnight W, Davies NM, MacNaughton WK, Wallace JL, Life Sci., 62, 77 (1998)
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR, Science, 284, 143 (1999)
Teitelbaum SL, Ross FP, Nat. Rev. Genet., 4, 638 (2003)
Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, McCabe S, Elliott R, Scully S, Kaufman S, Juan SC, Sun Y, Tarpley J, Martin L, Christensen K, McCabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, Boyle WJ, Proc. Natl. Acad. Sci. U.S.A., 97, 1566 (2000)
Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ, Endocr. Rev., 20, 345 (1999)
Haynes DR, Crotti TN, Zreiqat H, Biomaterials, 25, 4877 (2004)
Jung JY, Hong YJ, Choi YS, Jeong S, Lee WK, J. Mater. Sci. -Mater. Med., 20, 2441 (2009)
Marom R, Shur I, Solomon R, Benayahu D, J. Cell. Physiol., 201, 41 (2005)
Valta MP, Hentunen T, Qu Q, Valve EM, Harjula A, Seppanen JA, Vaananen HK, Harkonen PL, Endocrinology, 147, 2171 (2006)
Chang EJ, Ha J, Huang H, Kim HJ, Woo JH, Lee Y, Lee ZH, Kim JH, Kim HH, J. Cell Sci., 121, 2555 (2008)
Duque G, Rivas D, J. Bone Miner. Res., 22, 1603 (2007)
Arpornmaeklong P, Brown SE, Wang Z, Krebsbach PH, Stem Cells Dev., 18, 955 (2009)
Ringe JD, Faber H, Dorst A, J. Clin. Endocrinol. Metab., 86, 5252 (2001)
Inoue Y, Hisa I, Seino S, Kaji H, Exp. Clin. Endocrinol. Diabetes, 118, 719 (2010)
Boanini E, Torricelli P, Gazzano M, Fini M, Bigi A, Bone, 51, 944 (2012)
Schnitzler V, Fayon F, Despas C, Khairoun I, Mellier C, Rouillon T, Massiot D, Walcarius A, Janvier P, Gauthier O, Montavon G, Bouler JM, Bujoli B, Acta Biomater., 7, 759 (2011)
Deligianni DD, Katsala ND, Koutsoukos PG, Missirlis YF, Biomaterials, 22, 87 (2001)
Yuasa T, Miyamoto Y, Ishikawa K, Takechi M, Momota Y, Tatehara S, Nagayama M, Biomaterials, 25, 1159 (2004)
Shi Z, Huang X, Cai Y, Tang R, Yang D, Acta Biomater., 5, 338 (2009)
Moon HJ, Yun YP, Han CW, Kim MS, Kim SE, Bae MS, Kim GT, Choi YS, Hwang EH, Lee JW, Lee JM, Lee CH, Kim DS, Kwon IK, Biochem. Biophys. Res. Commun., 413(2), 194 (2011)
Cenni E, Granchi D, Avnet S, Fotia C, Salerno M, Micieli D, Sarpietro MG, Pignatello R, Castelli F, Baldini N, Biomaterials, 29, 1400 (2008)
Zhu Y, Mao ZW, Gao CY, Biomacromolecules, 14(2), 342 (2013)
Moreau JL, Xu HHK, Biomaterials, 30, 675 (2009)
Price PA, Annu. Rev. Nutr., 8, 865 (1988)
Lian JB, Stein GS, Crit. Rev. Oral Biol. Med., 3, 269 (1992)

[Referenced By]

[Related Articles]

[1] Rodan GA, Martin TJ, Science, 289, 1508 (2000)

[2] Boanini E, Torricelli P, Gazzano M, Giardino R, Bigi A, Biomaterials, 29, 790 (2008)

[3] van Beek E, Hoekstra M, van de Ruit M, Lowik C, Papapoulos S, J. Bone Miner. Res., 12, 1875 (1994)

[4] Luckman SP, Hughes DE, Coxon FP, Russell RGG, Rogers MJ, J. Bone Miner. Res., 13(4), 581 (1998)

[5] Dunford JE, Thompsin K, Coxon FP, Luckman SP, Hahn FM, Poulter CD, Ebetino FH, Rogers MJ, J. Pharmacol. Exp. Ther., 296, 235 (2001)

[6] Rodan GA, Fleisch HA, J. Clin. Invest., 97, 2692 (1996)

[7] Im GI, Qureshi SA, Kenney J, Rubash HE, Shanbhag AS, Biomaterials, 25, 4105 (2004)

[8] von Knoch F, Jaquiery C, Kowalsky M, Schaeren S, Alabre C, Martin I, Rubash HE, Shanbhag AS, Biomaterials, 26, 6941 (2005)

[9] Coleman R, Ann. N. Y. Acad., 1218, 3 (2011)

[10] Rogers MJ, Curr. Pharm. Des., 9, 2643 (2003)

[11] Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T, J. Clin. Invest., 104, 1363 (1999)

[12] Giuliani N, Pedrazzoni M, Negri G, Passeri G, Impicciatore M, Girasole G, Bone, 22, 455 (1998)

[13] Bone HG, Hosking D, Devogelaer JP, Tucci JR, Emkey RD, Tonino RP, Rodriguez-Portales J, Downs RW, Gupta J, Santora A, Liberman UA, N. Engl. J. Med., 350, 1189 (2004)

[14] Xiong Y, Yang HJ, Feng J, Shi ZL, Wu LD, J. Int. Med. Res., 37, 407 (2009)

[15] Lourwood DL, Pharmacotherapy, 18, 779 (1998)

[16] Monkkonen J, Simila J, Rogers MJ, Life Sci., 62, L95 (1998)

[17] Elliott SN, McKnight W, Davies NM, MacNaughton WK, Wallace JL, Life Sci., 62, 77 (1998)

[18] Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR, Science, 284, 143 (1999)

[19] Teitelbaum SL, Ross FP, Nat. Rev. Genet., 4, 638 (2003)

[20] Li J, Sarosi I, Yan XQ, Morony S, Capparelli C, Tan HL, McCabe S, Elliott R, Scully S, Kaufman S, Juan SC, Sun Y, Tarpley J, Martin L, Christensen K, McCabe J, Kostenuik P, Hsu H, Fletcher F, Dunstan CR, Lacey DL, Boyle WJ, Proc. Natl. Acad. Sci. U.S.A., 97, 1566 (2000)

[21] Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ, Endocr. Rev., 20, 345 (1999)

[22] Haynes DR, Crotti TN, Zreiqat H, Biomaterials, 25, 4877 (2004)

[23] Jung JY, Hong YJ, Choi YS, Jeong S, Lee WK, J. Mater. Sci. -Mater. Med., 20, 2441 (2009)

[24] Marom R, Shur I, Solomon R, Benayahu D, J. Cell. Physiol., 201, 41 (2005)

[25] Valta MP, Hentunen T, Qu Q, Valve EM, Harjula A, Seppanen JA, Vaananen HK, Harkonen PL, Endocrinology, 147, 2171 (2006)

[26] Chang EJ, Ha J, Huang H, Kim HJ, Woo JH, Lee Y, Lee ZH, Kim JH, Kim HH, J. Cell Sci., 121, 2555 (2008)

[27] Duque G, Rivas D, J. Bone Miner. Res., 22, 1603 (2007)

[28] Arpornmaeklong P, Brown SE, Wang Z, Krebsbach PH, Stem Cells Dev., 18, 955 (2009)

[29] Ringe JD, Faber H, Dorst A, J. Clin. Endocrinol. Metab., 86, 5252 (2001)

[30] Inoue Y, Hisa I, Seino S, Kaji H, Exp. Clin. Endocrinol. Diabetes, 118, 719 (2010)

[31] Boanini E, Torricelli P, Gazzano M, Fini M, Bigi A, Bone, 51, 944 (2012)

[32] Schnitzler V, Fayon F, Despas C, Khairoun I, Mellier C, Rouillon T, Massiot D, Walcarius A, Janvier P, Gauthier O, Montavon G, Bouler JM, Bujoli B, Acta Biomater., 7, 759 (2011)

[33] Deligianni DD, Katsala ND, Koutsoukos PG, Missirlis YF, Biomaterials, 22, 87 (2001)

[34] Yuasa T, Miyamoto Y, Ishikawa K, Takechi M, Momota Y, Tatehara S, Nagayama M, Biomaterials, 25, 1159 (2004)

[35] Shi Z, Huang X, Cai Y, Tang R, Yang D, Acta Biomater., 5, 338 (2009)

[36] Moon HJ, Yun YP, Han CW, Kim MS, Kim SE, Bae MS, Kim GT, Choi YS, Hwang EH, Lee JW, Lee JM, Lee CH, Kim DS, Kwon IK, Biochem. Biophys. Res. Commun., 413(2), 194 (2011)

[37] Cenni E, Granchi D, Avnet S, Fotia C, Salerno M, Micieli D, Sarpietro MG, Pignatello R, Castelli F, Baldini N, Biomaterials, 29, 1400 (2008)

[38] Zhu Y, Mao ZW, Gao CY, Biomacromolecules, 14(2), 342 (2013)

[39] Moreau JL, Xu HHK, Biomaterials, 30, 675 (2009)

[40] Price PA, Annu. Rev. Nutr., 8, 865 (1988)

[41] Lian JB, Stein GS, Crit. Rev. Oral Biol. Med., 3, 269 (1992)