화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.28, 45-53, August, 2015
DOI10.1016/j.jiec.2015.01.021  Export Citation
Functionalized mesoporous silica-coated magnetic graphene oxide by polyglycerol-g-polycaprolactone with pH-responsive behavior: Designed for targeted and controlled doxorubicin delivery
Ali Pourjavadi†, Zahra Mazaheri Tehrani, and Safura Jokar
  • Polymer Research Laboratory, Department of Chemistry, Sharif University of Technology, Azadi Avenue, P.O. Box 11365-9516, Tehran, Iran
E-mail:
In the present work a novel multifunctional drug nanocarrier was prepared. Polyglycerol-gpolycaprolactone was grafted on Mesoporous silica-coated magnetic graphene oxide. Doxorubicin, as anticancer drug, was loaded on this carrier. The in vitro drug release showed the controlled pH responsive behavior. At the endosomal pH (pH 5.5) the amount of drug release enhanced. This nanocarrier would have potential application in the tumor therapy owing to its biodegradability, controlled release and pH responsive behavior.
Keywords:Doxorubicin;Magnetic graphene oxide;Mesoporous silica;Polyglycerol;Polycaprolactone
  1. Yin P, Sun N, Deng C, Li Y, Zhang X, Yang P, Proteomics, 13, 2243 (2013)
  2. Huang X, Yin ZY, Wu SX, Qi XY, et al., Small, 7, 1876 (2011)
  3. Xu YX, Sheng KX, Li C, Shi GQ, ACS Nano, 4, 4324 (2010)
  4. Gilje S, Han S, Wang M, Wang KL, Kaner RB, Nano Lett., 7, 3394 (2007)
  5. Wang GS, Yang S, Wei ZY, Dong XF, Wang H, Qi M, Polym. Bull., 70(8), 2359 (2013)
  6. Lee C, Wei XD, Kysar JW, Hone J, Science, 321, 385 (2008)
  7. Peigney A, Laurent C, Flahaut E, Bacsa RR, Rousset A, Carbon, 39, 507 (2001)
  8. Jang BZ, Zhamu A, J. Mater. Sci., 43(15), 5092 (2008)
  9. Zhang L, Wang Z, Lu Z, Shen H, Huang J, Liu M, He N, Zhang Z, J. Mater. Chem. B, 1, 749 (2013)
  10. Stankovich S, Dikin DA, Dommett GHB, Kohlhaas KM, Zimney EJ, Stach EA, Piner RD, Nguyen ST, Ruoff RS, Nature, 442, 282 (2006)
  11. Ramanathan T, Abdala AA, Stankovich S, Dikin DA, Herrera-Alonso M, Piner RD, Adamson DH, Schniepp HC, Chen X, Ruoff RS, Nguyen ST, Aksay IA, Prud'homme RK, Brinson LC, Nat. Nanotechnol., 3(6), 327 (2008)
  12. Sengupta R, Bhattacharya M, Bandyopadhyay S, Bhowmick AK, Prog. Polym. Sci, 36, 638 (2011)
  13. Zhang YB, Tan YW, Stormer HL, Kim P, Nature, 438, 201 (2005)
  14. Nguyen DT, Charinpanitkul T, Park DW, Kim KS, J. Nanosci. Nanotechnol., 14, 7995 (2014)
  15. Sosnowski TR, J. Nanosci. Nanotechnol., 15, 3476 (2015)
  16. Gomez-Sotomayor R, Ahualli S, Viota JL, Rudzka K, Delgado AV, J. Nanosci. Nanotechnol., 15, 3507 (2015)
  17. Lu AH, Salabas EL, Schuth F, Angew. Chem.-Int. Edit., 46, 1222 (2007)
  18. Frey NA, Peng S, Cheng K, Sun SH, Chem. Soc. Rev., 38, 2532 (2009)
  19. Wang Y, Wang KY, Zhao JF, Liu XG, Bu J, Yan XY, Huang RQ, J. Am. Chem. Soc., 135(12), 4799 (2013)
  20. Li D, Muller MB, Gilje S, Kaner RB, Wallace GG, Nat. Nanotechnol., 3(2), 101 (2008)
  21. Li XL, Wang XR, Zhang L, Lee SW, Dai HJ, Science, 319, 1229 (2008)
  22. Wang ZM, Wang W, Coombs N, Soheilnia N, Ozin GA, ACS Nano, 4, 7437 (2010)
  23. Tasciotti E, Liu XW, Bhavane R, Plant K, Leonard AD, Price BK, Cheng MMC, Decuzzi P, Tour JM, Robertson F, Ferrari M, Nat. Nanotechnol., 3(3), 151 (2008)
  24. Wang Y, Shi W, Song WS, Wang L, Liu XG, Chen J, Huang RQ, J. Mater. Chem., 22, 14608 (2012)
  25. Jiang H, Zeng X, Xi Z, Liu M, Li C, Li Z, Jin L, Wang Z, Deng Y, He N, J. Biomed. Nanotechnol., 9, 674 (2013)
  26. Zarrabi A, Adeli M, Vossoughi M, Shokrgozar MA, Macromol. Biosci., 10, 383 (2010)
  27. Haag R, Sunder A, Stumbe JF, J. Am. Chem. Soc., 122(12), 2954 (2000)
  28. Adeli M, Haag R, Zarnegar Z, J. Nanopart. Res., 9, 1057 (2007)
  29. Zhang L, Xia K, Deng Y, Li S, Zhang C, Lu Z, He N, J. Nanosci. Nanotechnol., 14, 6458 (2014)
  30. Zhang L, Lu Z, Li X, Deng Y, Zhang F, Ma C, He N, Polym. Chem., 3, 1958 (2012)
  31. Zhang L, Lu Z, Bai Y, Wang T, Wang Z, Chen J, Ding Y, Yang F, Xiao Z, Ju S, Zhu J, He N, J. Mater. Chem. B, 1, 1289 (2013)
  32. Wilms D, Wurm F, Nieberle J, Bohm P, Kemmer-Jonas U, Frey H, Macromolecules, 42(9), 3230 (2009)
  33. Frey H, Haag R, Rev. Mol. Biotechnol., 90, 257 (2002)
  34. Calderon M, Warneckeb A, Garser R, Haag R, Kratz F, J. Control. Release, 132, e54 (2008)
  35. Kainthan RK, Janzen J, Kizhakkedathu JN, Devine DV, Brooks DE, Biomaterials, 29, 1693 (2008)
  36. Siegers C, Biesalski M, Haag R, Chem. Eur. J., 10, 2831 (2004)
  37. Su J, Flanagan J, Hemar Y, Singh H, Food Hydrocolloids, 20, 261 (2006)
  38. Sunder A, Mulhaupt R, Haag R, Frey H, Macromolecules, 33(2), 253 (2000)
  39. Roller S, Turk H, Stumbe JF, Rapp W, Haag R, J. Comb. Chem., 8, 350 (2006)
  40. Haag R, Stumbe JF, Sunder A, Frey H, Hebel A, Macromolecules, 33(22), 8158 (2000)
  41. Istratov V, Kautz H, Kim YK, Schubert R, Frey H, Tetrahedron, 59, 4017 (2003)
  42. Griffith LG, Acta Mater., 48, 263 (2000)
  43. Woodruff MA, Hutmacher DW, Prog. Polym. Sci, 35, 1217 (2010)
  44. Hummers WS, Offeman RE, J. Am. Chem. Soc., 80, 1339 (1958)
  45. Chen CM, Yang QH, Yang YG, Lv W, Wen YF, Hou PX, Wang MZ, Cheng HM, Adv. Mater., 21(29), 3007 (2009)
  46. Chen ZJ, Zhou L, Zhang FA, Yu CB, Wei ZB, Appl. Surf. Sci., 258(13), 5291 (2012)
  47. Tanga H, Guoa J, Sunb Y, Changa B, Renb Q, Yang W, Int. J. Pharm., 421, 388 (2011)
  48. Bucak S, Jones DA, Laibinis PE, Hatton TA, Biotechnol. Prog., 19(2), 477 (2003)
  49. Fu YS, Chen HQ, Sun XQ, Wang X, Appl. Catal. B: Environ., 111-112, 280 (2012)
  50. Zhu J, Liao L, Bian XJ, Kong JL, Yang PY, Liu BH, Small, 8, 2715 (2012)
  51. Zhang ZJ, Wang LM, Wang J, Jiang XM, Li XH, Hu ZJ, Ji YH, Wu XC, Chen CY, Adv. Mater., 24(11), 1418 (2012)