화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Journal of Industrial and Engineering Chemistry, Vol.30, 190-196, October, 2015
DOI10.1016/j.jiec.2015.05.021  Export Citation
Direct noncovalent conjugation of folic acid on reduced graphene oxide as anticancer drug carrier
Young Ho Park1, Sung Young Park2, 3, †, and Insik In1, 3, †
  • 1Department of Polymer Science and Engineering, Korea National University of Transportation, Chungju 380-702, South Korea
  • 2Department of Chemical and Biological Engineering, Korea National University of Transportation, Chungju 380-702, South Korea
  • 3Department of IT Convergence (Brain Korea PLUS 21), Korea National University of Transportation, Chungju 380-702, South Korea
E-mail:,
Conjugate of reduced graphene oxide with folic acid (rGO/FA) was prepared through a completely noncovalent functionalization method. rGO/FA conjugate was soluble in physiological media with high dispersion stability and enabled the accumulation of hydrophobic doxorubicin (DOX) and CdSe quantum dot (QD) as an anticancer drug and a fluorescent tag, respectively. rGO/FA conjugate loaded with DOX showed specific targeting to MDA-MB 231 cells, excellent drug-release efficiency and cytotoxicity in vitro. Considering the simplicity and extendibility of noncovalent functionalization methods, rGO/FA conjugate can be widely utilized for the designing of new graphene-based nanocarriers.
Keywords:Reduced graphene oxide;Noncovalent interaction;Folic acid;Targeted drug delivery;Anticancer drug carrier
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