화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Korean Journal of Chemical Engineering, Vol.33, No.1, 57-62, January, 2016
DOI10.1007/s11814-015-0037-7  Export Citation
Microfluidic room temperature ionic liquid droplet generation depending on the hydrophobicity and interfacial tension
Jung Wook Hwang, Joo-Hyung Choi1, Bumjoon Choi2, Gyudo Lee2, Sang Woo Lee2, Yoon-Mo Koo1, and Woo-Jin Chang†
  • Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N Cramer Street, Milwaukee, WI 53211, USA
  • 1Department of Biological Engineering, Inha University, 253 Yonghyun-dong, Nam-gu, Incheon 402-751, Korea
  • 2Department of Biomedical Engineering, Yonsei University, 1 Yonseidae-gil, Wonju, Gangwondo 220-710, Korea
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We have characterized micro-droplet generation using water immiscible hexafluorophosphate ([PF6])- and bis(trifluoromethylsulfonyl)imide ([Tf2N])-based room temperature ionic liquids (RTILs). The interfacial tension between total 7 RTILs and phosphate buffered saline (PBS) was measured using a tensiometer for the first time. PBS is one of the most commonly used buffer solutions in cell-related researches. The measured interfacial tension ranges from 8.51 to 11.62 and from 9.56 to 13.19 for [Tf2N]- and [PF6]-based RTILs, respectively. The RTILs micro-droplets were generated in a microfluidic device. The micro-droplet size and generation frequency were determined based on continuous monitoring of light transmittance at the interface in microchannel. The size of RTIL micro-droplets was inversely proportional to the increase of PBS solution flow rate and RTILs hydrophobicity, while droplet generation frequency was proportional to those changes. The measured size of RTILs droplets ranged from 0.6 to 10.5 nl, and from 1.0 to 17.1 nl for [Tf2N]- and [PF6]-based RTILs, respectively. The measured frequency of generated RTILs droplets ranged from 2.3 to 37.2 droplet/min, and from 2.7 to 17.1 droplet/min for [Tf2N]- and [PF6]-based RTILs, respectively. The capillary numbers were calculated depending on the RTILs, and ranged from 0.51×10.3 to 1.06×10.3 and from 5.00×10.3 to 8.65×10.3, for [Tf2N]- and [PF6]-based RTILs, respectively. The interfacial tension between RTILs and PBS will contribute to developing bioprocesses using immiscible RTILs. Also, the RTILs micro-droplets will enable the high-throughput monitoring of various biological and chemical reactions using RTILs as new reaction media.
Keywords:Interfacial Tension;Light Transmittance;Micro-droplet;Microfluidic Device;Water Immiscible Room Temperature Ionic Liquids (RTILs)
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